Calcimimetics as an Adjuvant Treatment for Familial Hypophosphatemic Rickets
نویسندگان
چکیده
منابع مشابه
Calcimimetics as an adjuvant treatment for familial hypophosphatemic rickets.
BACKGROUND AND OBJECTIVES The treatment for X-linked hypophosphatemia (XLH) with phosphate and calcitriol can be complicated by secondary hyperparathyroidism and nephrocalcinosis. Furthermore, vitamin D and phosphate stimulate FGF23 production, the pathogenic factor causing XLH. We investigated in XLH patients: 1) whether treatment with the calcimimetic agent, cinacalcet, will block the rise in...
متن کاملFamilial Hypophosphatemic Rickets: Pathophysiology and Medical Management
Chronic hypophosphatemia is one major cause of rickets and osteomalacia in growing children (see Preface of this volume). There are acquired and congenital forms. In most instances, the acquired forms can be controlled by acting on the underlying cause (insufficient phosphate intake, increased renal loss secondary to a mesenchymal tumor, or an altered renal tubular function). The inherited synd...
متن کاملTertiary hyperparathyroidism during high phosphate therapy of familial hypophosphatemic rickets.
We report the development of severe tertiary hyperparathyroidism in three girls treated for familial hypophosphatemic rickets and characterize parathyroid function in vivo and in vitro. All patients had been previously treated with relatively large doses of inorganic phosphorus (125 mm/day) and ergocalciferol or calcitriol for several years and had radiographic evidence of long-standing hyperpa...
متن کاملFamilial Hypophosphatemic Rickets - A Case Report and Review of Literature
Introduction Familial hypophosphatemic or X-linked hypophosphatemic (XLH) rickets is the most common form of non-nutritional rickets1. The prevalence of XLH rickets yet remain unknown in Bangladesh. It is an Xlinked dominant disorder characterized by renal phosphate wasting with consequent defect of bone mineralization1. Some form of the disease are observed to be transmitted which followed an ...
متن کاملFamilial hypophosphatemic rickets causing ocular calcification and optic canal narrowing.
In a case of familial hypophosphatemic rickets, marked bone thickening caused narrowing of the optic canals, resulting in bilateral optic atrophy. The case also showed metastatic calcification in the walls of both globes.
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2008
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.04981107